FADD - meaning and definition. What is FADD
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  3. FADD

What (who) is FADD - definition


FADD         
  • '''Extrinsic apoptosis pathway:''' The Fas receptor (FasR) is stimulated by Fas ligand (FasL), recruiting FADD to the FasR via an interaction between the death domains (DD) of both molecules. Procaspase 8 is recruited to FADD and interacts via the death effector domains (DED) of both molecules. This results in the cleavage and activation of procaspase 8, forming caspase 8, which goes on to cleave and activate other caspases such as procaspase 3 to initiate the caspase cascade which leads to cell death.
  • '''Regulation of FADD by MKRN1:''' MKRN1 ubiquitinylates FADD targeting it for degradation by the 26S proteosome. As it is degraded, FADD can no longer bind to the Fas receptor (Fas R) to induce apoptosis.
WIKIMEDIA DISAMBIGUATION PAGE
Fadd (disambiguation)
FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
https://en.wikipedia.org/wiki/FADD
faddism      
n. food faddism
CFLAR         
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
CASP8 and FADD-like apoptosis regulator; CASP8AP1; Casp8ap1; CLARP; Clarp; FLAME-1; Flame-1; I-FLICE; I-flice; MRIT; Mrit; USURPIN; Usurpin; C-FLIP; C-flip; C-FLIPL; C-flipl; C-FLIPR; C-flipr; C-FLIPS; C-flips; CFLAR (gene); FLIP protein
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).
https://en.wikipedia.org/wiki/CFLAR
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